NMR Platform
Nuclear Magnetic Resonance (NMR) spectroscopy is the most important tool for structure elucidation in all areas of chemistry, biology, food chemistry, medicine (Magnetic Resonance Imaging in vitro and in vivo) and chemistry of polymeric material (Mas-NMR ).
Technological advances in hardware and software have made the routine study of nuclei such as 13C, 2H, 19F, 15N e 31P possible. NMR is the most powerful and versatile spectroscopic technique that can provide information on the structure and the conformational features of molecules in solution. NMR has also become a valuable screening tool for the binding of ligands to protein targets and can provide structural information on the bound ligand.
Our group has studied the structure and the conformational features of various linear or cyclic pseudopeptides and carbohydrate mimics. Our experience ranges from the characterization of synthetic organic molecules or natural products to the study of interaction between ligands and biological macromolecules.
The NMR facilities include the Avance 600MHz Ultra Shield Plus and the Avance 400MHz Ultrashield spectrometers from Bruker, equipped with the Automatic Sample Changer. This device permits random sample access of up to 60 samples in each run, automatic instrument optimization and sending spectra via e-mail. Easy set-up procedures are accomplished via the dialog software ICON-NMR. The Bruker Avance 400MHz is equipped with a microimaging probe for proton and deuterium determination. Quantitative analysis of samples is performed with Eretic technology.
Scientific Director
Dr. Donatella Potenza graduated in Chemistry at the University of Milano. After a three-year fellowship on the synthesis of natural products, she became Researcher of Organic Chemistry at the same University working in the group of Professor Scolastico. Presently, her main research interests include structural and conformational analysis of biomolecules using NMR spectroscopy.
Dr. Donatella Potenza